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The role of chromosome stability in persistence, latency and reactivation of Mycobacterium tuberculosis

 
 

 

Date / Duration

2007-2009, 30 months

Funding

6th Framework Programme for Research and Technological Development of the European Commission (FP6); STREP

Budget

1'252'000 €

Partners

5 companies and universities from 4 countries

 

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Description

Tuberculosis causes more deaths than almost any other infectious agent. One-third of the world’s population is latently infected with the causative agent, Mycobacterium tuberculosis. To develop new drugs against tuberculosis, more knowledge about the biology of the pathogen and its persistence in the human host is needed.

Within the EU FP6 project CSI-LTB five partners from Europe and India have studied the mechanisms of DNA repair and genome integrity in M. tuberculosis. The project has been coordinated by Prof. Erik C. Böttger from the University of Zurich.

The studies conducted within CSI-LTB have greatly contributed to the knowledge of mechanisms involved in mycobacterial chromosome stability. The insights gained have been made available to the public and the scientific community by more than 15 publications.

With the work conducted, a novel strategy for therapies has been developed. This is expected to be of general use both to shorten the time period required to treat active disease and to eradicate latent tuberculosis.

Learn more about the scientific results in the final report.

Tasks EUrelations AG

EUrelations contributed substantially to the preparation of the successful proposal, was a partner in the project, supported the management and fulfilled certain dissemination activities.